| 孙梦雪,于婵婵,许敏,冯雪艳,姚立.化学通报,2020,83(10):866-874,918. |
| DNA机械技术的研究进展 |
| Advances in DNA Mechanical Technology |
| 投稿时间：2020-06-15 修订日期：2020-07-14 |
| DOI： |
| 中文关键词: DNA机械技术 分子机器 传感器 分子间相互作用 |
| 英文关键词:DNA mechanical technology Molecular machine Sensor Molecular Interaction |
| 基金项目:国家自然科学基金项目（21778055）和国家重点研发计划项目（2018YFA0208800）资助 |
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| 中文摘要: |
| 近年来DNA机械技术得到了广泛的关注和深入的研究。DNA独特的分子结构和理化性质使构建DNA机械装置成为可能。通过设计更加精巧的机械装置可以产生更加复杂的机械行为或功能。DNA机械技术在研究感知、传递和产生pN力的生物分子的基本特性方面发挥了重要作用，这些力学研究对于揭示它们的功能至关重要。本文总结了近年来DNA机械技术的研究进展。首先简要介绍DNA的机械力学基础，然后重点阐述几种DNA机械装置，最后讨论了DNA机械技术的挑战与展望。 |
| 英文摘要: |
| DNA mechanical technology has been widely concerned and deeply studied in recent years. Mechanical DNA devices have been enabled by the unique molecular structure and physical and chemical properties of DNA. More complex mechanical behavior or function can be achieved by designing more elaborate mechanisms. DNA mechanical technology has played important role in studies of the fundamental properties of the biomolecules that sense, transmit, and generate pN forces. Studies of the mechanics of these biomolecules are essential to revealing their functions. Here, we reviewed the latest progress in the study of DNA mechanical technology. First, the mechanical basis of DNA was briefly described. Especially several types of mechanical DNA devices were focused on. Finally, the challenges and prospects of DNA mechanical technology were discussed. |
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