| 安雪婕,李淼,秦婷,陈治明.化学通报,2021,84(3):273-278. |
| 3,3'-二取代联二萘酚硫脲催化合成4H-吡喃衍生物 |
| Syntheses of 4H-Pyran Derivatives Catalyzed by 3,3'-Disubstituted BINOL Thiourea |
| 投稿时间：2020-07-21 修订日期：2020-09-02 |
| DOI： |
| 中文关键词: 4H-吡喃衍生物 Knoevenagel-Micheal串联反应 3,3'-二取代BINOL 硫脲类催化剂 |
| 英文关键词:4H-pyran derivative Knoevenagel Michael series reaction 3,3'-disubstituted BINOL Thiourea catalysts |
| 基金项目:国家自然科学基金项目（21362006）资助 |
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| 中文摘要: |
| 合成了3种3，3'-二取代BINOL轴手性硫脲类催化剂（3a~3c），并成功地将其应用于催化不对称Knoevenagel-Micheal的串联反应。结果表明，以CH2Cl2为溶剂、3a为催化剂各种取代芳香醛与丙二腈和1，3-环己二酮在25℃下反应得到4H-吡喃衍生物，产率可达98%，对映选择性高达94%。 |
| 英文摘要: |
| Three 3,3'-disubstituted BINOL axial chiral thiourea catalysts(3a~3c) were synthesized and successfully applied to asymmetric Knoevenagel Micheal series reaction to synthesize a series of 4H-pyran derivatives. The results showed that the reaction of various substituted aromatic aldehydes with malononitrile and 1,3-cyclohexanedione at 25℃ using CH2Cl2 as solvent and 3a as the catalyst gave 4H-pyran derivatives with a yield of 98%, enantioselectivity up to 94%. |
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