| 韩刘雯琳,郭长彬.化学通报,2021,84(4):346-352. |
| Passerini多组分反应研究进展 |
| Progress in Passerini Multicomponent Reactions |
| 投稿时间：2020-09-15 修订日期：2020-10-12 |
| DOI： |
| 中文关键词: 多组分反应 Passerini反应 异腈 醛 羧酸 |
| 英文关键词:Multi-component reaction Passerini reaction Isocyanide Aldehyde Carboxylic acid |
| 基金项目:国家自然科学基金项目（30873140）、北京市自然科学基金项目（2182012）和科技创新服务能力建设-基本科研业务费（科研类）（025185305000/208）资助 |
|
| 摘要点击次数: 1024 |
| 全文下载次数: 0 |
| 中文摘要: |
| 多组分反应操作简便、原子经济性高，是一类重要的有机反应。经典Passerini反应是以异腈、醛酮、羧酸为原料一步合成α-酰氧基酰胺的多组分反应，其产物作为重要的有机中间体，可以进一步合成许多重要的药物、天然产物和功能材料等复杂有机分子，具有广泛的应用价值。本文从反应底物、串联反应及相关应用的角度阐述近5年来Passerini多组分反应研究的新进展。 |
| 英文摘要: |
| The multi-component reaction is an important type of organic chemical reactions, which has the characteristics of simple operation and high atom economy. The classic Passerini reaction is a multi-component reaction which use an isocyanide, an aldehyde (or a ketone) and a carboxylic acid to synthesize an α-acyloxycarboxamide in one pot. As a class of important organic intermediates, α-acyloxycarboxamides have a wide range of uses, and can be used to further synthesize many important complex organic molecules such as drugs, natural products and functional materials. This article summarizes the new progress of Passerini reactions in the past 5 years from the perspective of reaction substrates, tandem reactions and related applications. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |