| 张敏,李淼,秦婷,陈治明.化学通报,2021,84(5):480-485. |
| C2轴手性双胍催化叶立德和不饱和吖内酯的串联反应研究 |
| Tandem Reaction of Ylide and Unsaturated Azlactone Catalyzed by C2-axis Chiral Biguanide |
| 投稿时间：2020-10-13 修订日期：2020-12-20 |
| DOI： |
| 中文关键词: 轴手性胍 1，3-偶极环加成 分子内串联反应 |
| 英文关键词:Axial chiral guanidine 1,3-Dipole ring addition Intramolecular tandem reaction |
| 基金项目:国家自然科学基金项目（21362006）资助 |
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| 中文摘要: |
| 本文成功合成了4种基于联二萘酚骨架的手性双胍-酰胺类催化剂，并将其应用于邻羟基苯甲醛亚甲胺叶立德与不饱和吖内酯的1，3-偶极环加成和分子内串联反应。研究表明，在室温下以CHCl3作为溶剂、轴手性胍（1b，10（mol）%）作为催化剂，反应12h，能以较好的收率（73%～88%）和较高的对映选择性（72%～86%）得到苯并吡喃衍生物。 |
| 英文摘要: |
| In this paper, four chiral biguanide-amide catalysts based on the BINOL framework were successfully synthesized and applied to the 1,3-dipolar cycloaddition and intramolecular tandem reaction of o-hydroxybenzaldehyde ylide and unsaturated azlactone. Using CHCl3 as the solvent and axial chiral guanidine (1b, 10(mol)%) as the catalyst, reacting at room temperature for 12 hours, a series of benzopyran derivatives can be obtained with good yield (73%~88%) and high enantioselectivity (72%~86%). |
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