| 周莹,张艳.化学通报,2021,84(6):627-631,626. |
| 光催化应用于药物合成反应实验教学的设计与改革 |
| Design and Reform on Application of Photocatalysis to Experimental Teatching of Drug Synthesis Reactions |
| 投稿时间：2020-12-14 修订日期：2021-01-03 |
| DOI： |
| 中文关键词: 可见光催化 苝二酰亚胺 药物合成反应 |
| 英文关键词:Photocatalysis Perylene diimide Drug synthesis reactions |
| 基金项目:国家级一流本科专业建设项目、江苏省品牌专业建设工程二期项目和江南大学课程思政研究专项（JG2019048）资助 |
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| 中文摘要: |
| 可见光诱导的光催化具有绿色、高效、可持续等特点，在有机医药中间体和药物分子的合成上极具创新性。近年来，将前沿性、创新性的科研成果实施于本科实验教学项目中已成为高校实验教学改革的重点与趋势之一。本实验利用苝二酰亚胺作为光催化剂，在温和的光照条件下高效选择性氧化硫醚得到亚砜。通过本实验的学习，为学生实践绿色、低能耗的有机化学提供了理想的平台，拓展了学生对当今合成技术前沿的视野，调动了对于合成新技术、新应用的兴趣，激发了挑战传统合成手段的热情，培养了科研创新理念以及独立思考、分析解决问题的能力。 |
| 英文摘要: |
| Photocatalysis induced by visible light is green, efficient and sustainable, which is very innovative in the synthesis of organic pharmaceutical intermediates and drug molecules. Application of the cutting-edge and innovative scientific research results into the undergraduate experimental teaching projects has become one of the focuses and trends of the reform of experimental teaching in universities. In this program, perylene diimide was used as a photocatalyst to obtain sulfoxide by selective sulfide under mild illumination conditions. Through this experiment, we provide an ideal platform for students to practice green, low energy consumption of organic chemistry, expand the students for today's synthetic technological frontier field of vision, mobilize the interest for the synthesis of new technology, new application, stimulated the enthusiasm of the challenge to the traditional synthetic method, cultivating the concept of scientific research innovation and independent thinking with problem-solving skills. |
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