| 韩玉,胡茂群,张梦瑶,田晨曦,王程宇.化学通报,2021,84(9):867-881. |
| 萘并呋喃类化合物的合成研究进展 |
| Progress in Synthesis of Naphthofurans |
| 投稿时间：2021-03-01 修订日期：2021-03-25 |
| DOI： |
| 中文关键词: 萘并呋喃 合成 环化反应 串联反应 |
| 英文关键词:Naphthofurans Synthesis Cyclization Tandem reactions |
| 基金项目:国家自然科学基金项目(21702088) |
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| 中文摘要: |
| 萘并呋喃是一类重要的有机芳杂环,其分子骨架不仅是许多天然产物、药物分子的核心结构,而且还是重要的有机合成中间体,在材料化学中也具有广泛的应用价值。因此,萘并呋喃及其衍生物的合成一直是有机合成的研究热点之一。本文将对已有的萘并呋喃类化合物的主要合成策略、方法,结合我们小组的部分研究工作进行综述,包括如下几个方面：1)碱或酸促进的环化反应；2)过渡金属催化的串联环化反应；3)自由基引发的环化反应；4)其他非金属催化的环化反应,并展望了萘并呋喃衍生物合成的研究和发展方向。 |
| 英文摘要: |
| Naphthofurans, an important class of heteroaromatic molecules, are not only the key structural motifs in many natural products and pharmaceutical compounds, but also an valuable intermediate in organic synthesis and they also have wide application in material chemistry. These make the synthesis of naphthofuran and its derivatives have been one of the hotspots in organic synthesis. In this paper, the main synthetic strategies or methods of naphthofurans are reviewed, combining with our group"s related work, including:1) Cyclization promoted by base or acid; 2) Transition metal catalyzed tandem cyclization; 3) Radical initiated cyclization; 4) Other nonmetallic catalyzed cyclization. And the research and development of the synthesis of naphthofuran derivatives are also prospected in this text. |
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