| 李仪晴,李小玉,白晶晶,李虎,张涛.化学通报,2021,84(9):895-899. |
| 改良的橘皮果胶抑制半乳糖凝集素-3与肿瘤相关功能的研究进展 |
| Research progress of modified citrus pectin on inhibiting galectin-3 function related on tumor |
| 投稿时间：2021-03-01 修订日期：2021-04-08 |
| DOI： |
| 中文关键词: 改良的橘皮果胶 半乳糖凝集素-3 抗肿瘤 |
| 英文关键词:Modified citrus pectin Galectin-3 Antitumor |
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| 中文摘要: |
| 半乳糖凝集素-3(galectin-3,Gal-3)是半乳糖凝集素家族中唯一一种嵌合体结构蛋白,含有一个特定的糖基识别结构域,能够特异性识别并结合半乳糖,此结构域可介导细胞与细胞之间的黏附和识别,并且能够促进部分肿瘤细胞的增殖和转移等。改良的橘皮果胶(modified citrus pectin, MCP)可通过特异性结合肿瘤相关蛋白Gal-3糖基识别结构域,抑制Gal-3与其相关肿瘤受体的结合,阻断肿瘤细胞之间相关信号的传导,从而表现出较强的抗肿瘤活性。本文综述了MCP在Gal-3介导肿瘤发生发展过程中相关作用的研究进展。 |
| 英文摘要: |
| Galectin-3 (Gal-3) is the only chimeric structural protein in the galectin family and contains a specific carbohydrate recognition domain (CRD) that can specifically recognize and bind galactose. The CRD can mediate cell-cell adhesion and recognition and can promote the proliferation and metastasis of some tumor cells. Modified citrus pectin (MCP) can specifically inhibit the binding of Gal-3 to its related tumor receptors by interacting with the tumor-associated protein Gal-3 to block the related signals between tumor cells conduction, thus showing strong antitumor activities. This study reviews the research progress of MCP on Gal-3-mediated tumorigenesis and development. |
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