| 吴江龙,王彦,李典军,杨金会.化学通报,2021,84(12):1328-1337. |
| 通过C(sp3)-H键活化构建C-P键合成氨基膦酸酯类化合物 |
| Progress in the Synthesis of Aminophosphonates Compounds by Forming C-P Bonds via C(sp3)-H Activation |
| 投稿时间：2021-04-08 修订日期：2021-04-28 |
| DOI： |
| 中文关键词: 过渡金属催化 非金属催化 C(sp3)-H键活化 C-P键 氨基膦酸酯药物 |
| 英文关键词:transition metal-catalyzed metal-freecatalyzed C(sp3)-H activation C-P bond aminophosphonates |
| 基金项目:宁夏回族自治区重点研发计划项目(2019BDE03002，2021BEG02001,2021BEE03003)、国家自然科学基金项目(21861031,21362025)、宁夏国家一流学科建设项目(NXYLXK2017A04)和宁夏高等学校科学研究项目(NGY2018005)资助 |
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| 中文摘要: |
| 氨基膦酸酯及其衍生物是一种重要的有机化合物，因其具有抗菌、抗真菌、酶抑制剂和催化抗体活性而广泛应于药物化学和农业化学。通过C(sp3)-H键活化构建C-P键的方法是合成氨基膦酸酯衍生物重要方法之一。本文以过渡金属体系和非金属体系进行分类，介绍了近年来通过C(sp3)-H键活化方法构建C-P键合成氨基膦酸酯类化合物的研究进展。 |
| 英文摘要: |
| Amino phosphonates and their corresponding amino phosphonic acids are essentially organic compounds. Moreover, α-amino phosphonates have broad applications ranging from pharmaceutical chemistry to agricultural chemistry due to their antibacterial, antifungal, enzyme inhibitory, and catalytic antibody activities. It is a primary method for synthesizing functional amino phosphonate compounds using transition metal-catalyzed and metal-free catalyzed by cross-coupling reaction to form C-P bond. Mainly, it is undeniably attractive to synthesize amino phosphonate compounds by forming C-P bonds via C(sp3)-H activation. This paper summarizes the recent advances in synthesizing amino phosphonate compounds by forming C-P bonds via C(sp3)-H activation. For a start, the recent advances in the development of the synthesis of amino phosphonates by forming C-P bonds via C(sp3)-H activation are surveyed based on various transition-metal-catalyzed (such as: copper-catalyzed, cobalt-catalyzed, iron-catalyzed, iridium-catalyzed). Moreover, recent developments in this field have been demonstrated based on various metal-free catalyzed (such as: photocatalytic, electrochemistry) types. Taken together, the above results have opened new avenues toward the more mild, efficient and green synthesis of essential amino phosphonate compounds. |
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