| 尚青青,白阳,杨靖,步怀天.化学通报,2022,85(3):287-296. |
| 基于柱芳烃主客体作用构筑的超分子纳米载体 |
| Supramolecular nanocarriers based on the host-guest interactions of pillararene |
| 投稿时间：2021-06-10 修订日期：2021-07-26 |
| DOI： |
| 中文关键词: 柱芳烃 主客体识别作用 纳米载体 |
| 英文关键词:pillararene, host-guest interactions, nanocarriers |
| 基金项目:国家自然科学基金项目(21801162)资助 |
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| 中文摘要: |
| 近年来，基于大环分子主客体作用构筑的超分子纳米载体因其动态响应的自组装性质受到广泛关注，并在肿瘤治疗纳米载体领域展现出潜在的应用价值。其中，柱芳烃作为一类新型的大环分子,因其高度对称的刚性结构、易于功能化以及优异的主客体络合能力等优点，成为近年来的超分子纳米载体领域的研究热点。本文根据柱芳烃基纳米载体治疗机制的不同，从化疗，光动力治疗，以及联合治疗三个方面对其性能和应用方面进行总结和评述，并在此基础上对柱芳烃基纳米载体的研究方向和发展趋势进行展望。 |
| 英文摘要: |
| In recent years, supramolecular nanocarriers based on the host-guest interaction have attracted lots of attention in the field of cancer therapy field due to their unique self-assembly properties. As a new type of macrocyclic molecule, pillararenes have become a hot spot in recent years on account of their unique chemical structure and superior host-guest inclusion ability. Based on the different therapeutic mechanisms, pillararenes-based nano carriers and their applications in chemotherapy, photodynamic therapy, and combined therapy fields are summarized in this paper. On this basis, the research interests and development trend are also expected based on the progress of pillararenes-based nano-carriers. |
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