| 王晓霞,欧玉姣,张生芳,刘 荣.化学通报,2022,85(3):309-316. |
| 医药中间体阿糖腺苷的制备方法研究进展 |
| The Research Progress in the Preparation of Pharmaceutical Intermediate Vidarabine |
| 投稿时间：2021-07-01 修订日期：2021-08-24 |
| DOI： |
| 中文关键词: 阿糖腺苷 制备方法 综述 化学合成法 生物合成法 |
| 英文关键词:Vidarabine, Preparation method, review, Chemical synthesis, Biosynthesis |
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| 中文摘要: |
| 阿糖腺苷(Ara-A)是一种广谱的DNA病毒抑制剂,在临床上可用于治疗单纯疱疹病毒性脑炎。其衍生物如单磷酸阿糖腺苷、氟达拉滨也在相关疾病治疗方面疗效显著。其制备方法包括化学合成法和生物合成法,化学合成法原料多变、合成方法多样；生物合成法的研究集中在酶法,关键工艺在于酶的制备。本文综述了阿糖腺苷制备方法最新研究进展,并展望其应用前景。 |
| 英文摘要: |
| Vidarabine (Ara-A) is a broad-spectrum DNA virus inhibitor, which has been used clinically for the treatment of herpes simplex encephalitis, and also be used for treat herpes zoster and varicella from immunosuppressed patients infected. Its derivatives such as Vidarabine Monophosphate and Fludarabine are also effective in the treatment of related diseases. The preparation method comprises: chemical synthesis and biosynthesis. in the early 1960s, Vidarabine was first successful synthesized through chemical synthesis. Subesequently, In the late 1960s, Vidarabine was obtained with enzymatic method in biosynthesis. The characteristic of chemical synthesis is a wide range of raw materials, and synthesis method varies; biosynthesis research focused on enzymatic methods, and the key process is the preparation of enzymes. Since both the two approaches have their advantages and disadvantages, it can be used in the practical production. The latest progress in the preparation of Vidarabine was reviewed and the prospect was also discussed in this paper. |
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