| 梁俸铭,邵利辉,付毅红,王贞超,欧阳贵平.化学通报,2022,85(5):575-582. |
| 合成源1,4-萘醌类化合物抑菌活性研究进展 |
| Research Progress in Antibacterial Activities of Synthetic 1,4-Naphthoquinone Compounds |
| 投稿时间：2021-08-18 修订日期：2021-09-09 |
| DOI： |
| 中文关键词: 1,4-萘醌衍生物 抑菌活性 构效关系 |
| 英文关键词:1,4-Naphthoquinone derivatives, Antibacterial activity, Structure activity relationship |
| 基金项目:国家自然科学基金项目(21867004,22007022)资助 |
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| 中文摘要: |
| 1,4-萘醌作为广泛存在的一种物质，其生物活性尤其是抗菌作用受到越来越多的关注。本文对不同取代类型的合成源1,4-萘醌衍生物进行总结,并探讨其抑菌活性及构效关系，发现在1,4-萘醌的2位引入含氨基取代、含硫取代的基团能够提高抗菌活性，且通常含硫取代比氨基取代基团的抗菌活性高。期望本文能为1,4-萘醌类抗菌药物的研发提供参考。 |
| 英文摘要: |
| 1,4-Naphthoquinone is a widely existing substance, and its biological activity has attracted more and more attention, especially in antibacterial aspects. This article summarizes the synthetic 1,4-naphthoquinone derivatives of different substitution types, and discusses their antibacterial activities and structure-activity relationship. It is found that the introduction of amino-substituted and sulfur-containing substitutions at 2-position of 1,4-naphthoquinone can improve the antibacterial activity, and the antibacterial activity of the sulfur-containing substitution is generally higher than that of the amino substitution group. It is hoped that this article can provide a reference for the future research and development of 1,4-naphthoquinone antibacterial drugs. |
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