| 何珺.化学通报,2022,85(6):717-721. |
| 单取代芳烃对位选择性碳氢活化反应研究 |
| Study on para- Selectivity of Monosubstituted Aromatics in Carbon Hydrogen Activation |
| 投稿时间：2021-09-23 修订日期：2021-09-30 |
| DOI： |
| 中文关键词: 单取代芳烃 对位选择性 羰基导向 交叉脱氢偶联 碳氢活化 |
| 英文关键词:Monosubstituted arenes, para- selectivity, Carbonyl directed, Cross dehydrogenation coupling, Carbon hydrogen activation |
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| 中文摘要: |
| 以单取代芳烃为芳基化试剂,以羰基为导向定位基团,研究了单取代芳烃对位选择性的与芳香酮的交叉脱氢偶联反应。该方法的高选择性一方面体现在用作芳基化试剂的单取代芳烃能够单一选择性的发生对位碳氢活化,并生成对位取代产物。另一方面,作为弱导向基团的羰基具有优秀的邻位导向定位作用,高选择性的发生羰基邻位碳氢键活化。此外,该方法还具有反应条件温和、反应效率高、底物范围广、氧化剂廉价易得等优点,为对位取代联芳基化合物的合成提供了一条切实可行的途径。 |
| 英文摘要: |
| Using monosubstituted arenes as the arylation reagent and the carbonyl as the directing group, the para- selective cross dehydrogenation coupling reaction of monosubstituted aromatics with aromatic ketones was developed and investigated. On the one hand, monosubstituted aromatics as the arylation reagent can deliver high para- selectivity, and only para- selected products were generated. On the other hand, the carbonyl group, which was chosen as the directing group, can direct the ortho carbon hydrogen bond activation with high selectivity. In addition, this approach also has the advantages of mild reaction conditions, high reaction efficiency, wide substrates range scope and cheap availability oxidants, which provides a practical way for the synthesis of para- substituted diaryl compounds. |
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