| 江泽琦,马丽欣,邓德茹,凌永社.化学通报,2022,85(7):816-820. |
| Arbuzov重排反应合成烷基膦酸酯的研究进展 |
| Research Progress on the Synthesis of Alkyl Phosphonates by Arbuzov Rearrangement Reaction |
| 投稿时间：2021-11-04 修订日期：2021-12-27 |
| DOI： |
| 中文关键词: 催化剂 P－C键 烷基膦酸酯 Michaelis-Arbuzov重排 微反应技术 |
| 英文关键词:catalyst P－C bond alkyl phosphonates Michaelis-Arbuzov rearrangement micro-reaction technology |
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| 中文摘要: |
| 烷基膦酸酯是一类具有多种生物活性的有机磷化合物，在农业和医药化工领域具有广泛的应用。本文介绍了Michaelis-Arbuzov重排反应构建P－C键合成烷基膦酸酯类化合物的方法，着重阐述了通过催化剂、微波、超声波等促进的绿色环保的Arbuzov重排反应。特别是在连续流动条件下，通过微反应进行的无溶剂Arbuzov重排反应，能够缩短反应时间，提高反应效率，使烷基磷酸酯的合成具有更广阔的应用前景。 |
| 英文摘要: |
| As a kind of organic phosphorus compounds with various biological activities, alkyl phosphonates have been widely applied in agriculture and medicine. In this paper, the principle of constructing P－C bond to synthesize alkyl phosphonates by Michaelis-Arbuzov rearrangement reaction was introduced. And the environmentally friendly Arbuzov rearrangement reaction promoted by catalyst, microwave and ultrasonic wave were summarized. Especially, the solvent-free Arbuzov rearrangement reaction by micro-reaction under continuous flow conditions could shorten the reaction time and improve the reaction efficiency, which provides the synthesis of alkyl phosphates with a broader application prospect. |
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