| 许根瑞,李伟强,吴沁,黄超.化学通报,2022,85(8):981-986. |
| 微波辅助酸催化水相一锅高效合成吖啶酸 |
| Microwave-Assisted Acid Catalyzed One-Pot Efficient Synthesis of Acridine Acid in Aqueous Phase |
| 投稿时间：2021-12-29 修订日期：2022-01-25 |
| DOI： |
| 中文关键词: 吖啶酸 微波辅助 一锅法 酸催化 绿色化学 |
| 英文关键词:Acridine acid, Microwave assisted, One pot method, Acid catalysis, Green chemistry |
| 基金项目:国家自然科学基金项目(21662046,21202142)资助 |
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| 中文摘要: |
| 本文建立一种以去离子水为溶剂，在微波辅助酸催化下一锅串联高效合成吖啶酸的新方法，该反应条件温和、操作简单、绿色高效。在优化反应条件下我们考察了多种取代基团对反应的影响，结果显示该方法具有良好的适应性，以83% ~ 97%收率得到12个吖啶酸化合物。所有化合物结构均经过1H NMR、13C NMR、HRMS、熔点等表征确认。 |
| 英文摘要: |
| In this paper, a new method of one-pot series efficient synthesis of acridine carboxylic acid catalyzed by microwave-assisted acid with deionized water as solvent is established. The reaction conditions are mild, easy to operate, green and efficient. Under the optimized reaction conditions, we investigated the influence of various substituent groups on the reaction. The results showed that the method had good adaptability, and 12 acridine carboxylic acid compounds were obtained in 83% ~ 97% yield. All compounds were characterized by 1H NMR, 13C NMR, HRMS and melting point. |
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