贾瑞龙,秦晓瑶,华其灼灼,刘雷.化学通报,2022,85(8):976-980.
丙烯醇反马氏水合制备1,3-丙二醇
Preparation of 1,3-Propanediolby Anti-Markovnikov Hydration of Allyl Alcohol
投稿时间:2022-01-20  修订日期:2022-02-11
DOI:
中文关键词:  甘油  丙烯醇  1,3-丙二醇  反马氏水合
英文关键词:Glycerol  Allyl alcohol  1,3-Propanediol  Anti-Markovnikov hydration
基金项目:国家自然科学基金项目(U1910202,21978194)、山西中医药大学博士科研启动基金项目(2020BKS05,2020BK14)和山西中医药大学中药学科建设项目(1008Z3)资助
作者单位E-mail
贾瑞龙 山西中医药大学中药与食品工程学院 jiarl2009@163.com 
秦晓瑶 山西中医药大学  
华其灼灼 山西中医药大学  
刘雷 太原理工大学  
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中文摘要:
      1,3-丙二醇具有很高的经济价值,是合成纤维聚对苯二甲酸丙二酯的重要原料。基于甘油甲酸介入法获得的丙烯醇作为平台分子,通过丙烯醇与TiCl4-NaBH4反应,首次实现常温常压下1,3-丙二醇的制备, 为1,3-丙二醇的合成提供了一条新的路径。在最优条件下,1,3-丙二醇的产率68.73%,推测反应机理为:TiCl4和NaBH4发生反应,生成中间体 “BH3”,进而实现了丙烯醇反马氏水合制备1,3-丙二醇。
英文摘要:
      1,3-Propanediol as an important polypropylene terephthalate raw material has high economic value. Formic acid mediated deoxydehydration of glycerol to allyl alcohol which was used as platform molecule. 1, 3-Propanediol was prepared by the reaction of allyl alcohol with TiCl4-NaBH4 at room temperature and pressure for the first time, which provided a new path for the synthesis of 1,3-propanediol. Under the optimal conditions, the yield of 1,3-propanediol was 68.76%. It was speculated that the reaction mechanism was as follows: TiCl4 reacted with NaBH4 to generate intermediate "BH3", and then preparation of 1,3-propanediol by anti-Markovnikov hydration of allyl alcohol was realized.
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