| 代柏妍,常明,陈龙飞,刘郡,刘兆蒙,徐彩霞,支德福.化学通报,2022,85(10):1186-1195,1242. |
| 微针的制备及应用研究 |
| Study on preparation and application of microneedles |
| 投稿时间：2022-03-06 修订日期：2022-04-14 |
| DOI： |
| 中文关键词: 微针 微针制备 微针的应用 可溶性微针 固体微针 |
| 英文关键词:Microneedle Microneedle preparation Application of microneedles Dissolving microneedles Solid microneedle |
| 基金项目:国家自然科学基金项目(21503035)、辽宁省民族创新联合基金项目(2020-MZLH-28)、大连市高层次人才创新支持计划项目(2018RQ33)和大学生科技创新项目(202112026174)资助 |
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| 中文摘要: |
| 本文主要针对微针的材质、分类、设计、制备与加工方法进行分析，例举了金属、硅、高分子聚合物和一些其他的微针材料。同时也对微针的应用，例如经皮给药的方法、途径、影响进行说明，也对其作用于糖尿病、皮肤病和其他疾病及其复合应用进行了简单分析。高分子聚合物微针和新型微针的发展可以显著提高药物的透皮速率和分子量，但是在安全性上还有待进一步研究。 |
| 英文摘要: |
| This paper mainly focuses on the material, classification, design, preparation and processing methods of the microneedle, including metal, silicon, polymer and some other microneedle materials. At the same time, the application of microneedles, such as the method of transdermal drug delivery, approach, influence are explained, and its effect on diabetes, skin disease and other diseases and their compound application are simply analyzed. The development of polymer microneedles and novel microneedles can significantly improve the transdermal rate and molecular weight of drugs, but their safety needs further study. |
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