冯宇.化学通报,2022,85(11):1397-1401.
本科生有机化学实验与前沿科学研究的融合—四(4-甲基苯基)乙烯的合成、表征及聚集发光性能研究
The Fusion of Undergraduate Organic Chemistry Experiments and Research Frontiers: Synthesis, Characterization and Aggregation-induced Emission of Tetrakis(4-methylphenyl)ethylene
投稿时间:2022-04-01  修订日期:2022-04-11
DOI:
中文关键词:  四(4-甲基苯基)乙烯  聚集诱导发光  紫外-可见光谱  荧光  有机化学实验
英文关键词:tetrakis(4-methylphenyl)ethylene  Aggregation-induced emission  UV-Vis spectroscopy  Fluorescence  Organic chemistry experiment
基金项目:国家自然科学基金项目(21871270)资助
作者单位E-mail
冯宇 常州大学材料科学与工程学院 fengyu211@iccas.ac.cn 
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中文摘要:
      四苯乙烯(TPE)及其衍生物,作为一类典型的聚集诱导发光分子,由于其合成简单、易于修饰和发光性能优异等优点,已被广泛的应用于化学生物传感器、生化检测、生物成像和有机光电材料等领域。在此,我们将聚集诱导发光这一前沿研究热点融入有机化学实验教学中,进行教学对象为化学专业本科生的前沿有机化学实验设计:四(4-甲基苯基) 乙烯的合成、表征及聚集发光性能研究。该实验内容包括通过McMurry 偶联反应合成四(4-甲基苯基) 乙烯、四(4-甲基苯基) 乙烯的结构表征,以及利用紫外-可见分光光度计和荧光光谱仪对其聚集诱导发光性能进行研究。通过本实验,使学生了解聚集诱导发光这一科学研究前沿领域,激发学生对科学研究的兴趣、拓展科研视野、激发科研热情、培养学生的科研探究能力。本实验综合了有机化学、仪器分析和发光材料等知识点的学习,培养学生的实验操作技能,提升学生的综合及创新能力,建议纳入高年级中级有机化学实验课程。
英文摘要:
      Tetraphenylethylene (TPE) and its derivatives, as a typical class of aggregation-induced emission (AIE) molecules, have been widely used in chemical biosensors, biochemical probes, bioimaging and organic optoelectronics due to their advantages of simple synthesis, easy modification and excellent fluorescence properties. Herein, we integrate the frontier research hotspot of aggregation-induced emission into the teaching of organic chemistry experiments, a frontier organic chemistry experiment, “synthesis, characterization and aggregation emission properties of tetrakis(4-methylphenyl)ethylene (TMPE)”, which is recommended for undergraduates. The content of this experiment includes the synthesis of TMPE by McMurry coupling reaction, the structure characterization of TMPE, and the study of aggregation-induced emission properties using UV-Vis absorption and fluorescence spectroscopy. Through this experiment, students can understand the frontier field of scientific research of aggregation-induced emission, stimulate students" interest in scientific research, expand scientific research horizons and cultivate students" scientific research ability. This experiment integrates the learning of organic chemistry, instrumental analysis and luminescent materials, which can cultivate students" experimental operation skills and improve students" comprehensive and innovative ability. Thus, this organic chemistry experiment should be arranged for junior university students.
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