| 谭画元,张广龙,吉礼涛,王钦,卢奕朵,欧阳贵平,王贞超,李洙锐.化学通报,2023,86(3):300-305. |
| 二氢吲哚-2,3-二酮衍生物抑菌活性研究进展 |
| Research progress on antibacterial activity of indoline-2,3-dione derivatives |
| 投稿时间：2022-07-29 修订日期：2022-09-08 |
| DOI： |
| 中文关键词: 二氢吲哚-2,3-二酮 抑菌活性 研究进展 |
| 英文关键词:Indoline-2,3-dione, antibacterial activity, research progress |
| 基金项目:国家自然科学基金项目(21867004,22007022)、贵州省科技计划平台项目(黔科合平台人才20185781)和贵州省科技计划项目(黔科合基础-ZZK[2021]重点034)资助 |
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| 中文摘要: |
| 二氢吲哚-2,3-二酮是一种结构简单且应用广泛的药物小分子，其衍生物的合成、结构和药理活性等备受关注。已有报道表明二氢吲哚-2,3-二酮具有抗菌、抗衰老、降血脂、抗癫痫、抗病毒等多种生物活性。本文主要围绕抑菌生物活性，对国内外关于二氢吲哚-2,3-二酮类化合物的构效关系进行分析总结，为后期该类新型抗菌化合物的设计合成提供参考。 |
| 英文摘要: |
| Indoline-2,3-dione is a small drug molecule with simple structure and wide application. The synthesis, structure and pharmacological activity of its derivatives have attracted much attention. It has been reported that indoline-2,3-dione has various biological activities such as antibacterial, antiaging, hypolipidemic, antiepileptic and antiviral activities. This paper mainly focuses on the antibacterial biological activity, and analyzes and summarizes the structure-activity relationship of indoline-2,3-dione compounds at home and abroad, and provides a reference for the design and synthesis of such new antibacterial compounds in futrue. |
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