| 李海萌,董琦,尚会建.化学通报,2023,86(5):617-623. |
| SalenMn(Ⅲ)催化非活化烯烃的不对称溴胺化反应研究 |
| SalenMn(Ⅲ)Catalyzed Asymmetric Bromamination of Unactivated Olefins |
| 投稿时间：2022-10-24 修订日期：2022-11-23 |
| DOI： |
| 中文关键词: 氮杂环化合物 溴胺化反应 亲核取代 对映选择性 |
| 英文关键词:Nitrogen heterocyclic compounds, Bromamination reaction, Nucleophilic substitution, Enantioselectivity |
| 基金项目:河北省自然科学基金重点项目(B2020208095)资助 |
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| 中文摘要: |
| 对SalenMn(Ⅲ)催化的非活性烯烃溴胺化反应进行研究,考察催化剂、溶剂、溴化试剂、温度和时间对反应产率和对映体过量(ee)值的影响。研究发现,当Cat.1为催化剂、氯代苯为溶剂和次溴酸钠为溴化试剂在10°C下反应6h,反应产率最高为88%,ee(对映体过量值)最高为93%。此方法为构建手性氮杂环化合物提供了新选择。 |
| 英文摘要: |
| The bromoamination of unactive olefin catalyzed by SalenMn(Ⅲ) chiral ligand was studied. The effects of catalyst, solvent, bromine source, temperature and time on the reaction yield and enantioselectivity were investigated. It was found that when Cat.1 was the catalyst, chlorobenzene was the solvent and sodium hypobromite was the bromine source at 10°C for 6h, the reaction yield was 88% and the enantiomeric excess (ee) value was 85%. This method provides a new choice for the construction of chiral nitrogen heterocyclic compounds. |
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