| 赵相平,何杰芳.化学通报,2023,86(10):1208-1215,1198. |
| 核磁共振-光学成像双模态探针研究进展 |
| Advances in Dual-Mode Probes for Nuclear MagneticResonance-Optical Imaging |
| 投稿时间：2022-12-29 修订日期：2023-02-07 |
| DOI： |
| 中文关键词: 双模态探针 超顺磁性氧化铁纳米颗粒 钆类螯合物 锰氧化物纳米颗粒 |
| 英文关键词:Bimodal probes, Superparamagnetic iron oxide nanoparticles, Gadolinium chelates, Manganese oxide nanoparticles |
| 基金项目:国家自然科学基金（NSFC21867005）；贵州省科技计划项目黔科合基础（20201Y430）；贵州省高层次留学人才创新创业择优资助项目（2019）12 号；贵州省研究生科研基金立项课题项目黔教合YJSCXJH（2020）098；贵州师范大学2018年度学术新苗培养及创新探索专项项目黔科合平台人才（20185769-12）。 |
|
| 摘要点击次数: 822 |
| 全文下载次数: 165 |
| 中文摘要: |
| 癌症是致人死亡的一大诱因,但癌症早期瘤体积微小,常规的身体检查和影像学检查难以发现。近年来,探针对癌症的精确检测能力被广泛关注。本综述就目前研究的超顺磁性氧化铁纳米颗粒、钆类螯合物或锰氧化物纳米颗粒作为核磁共振成像部分的MRI-OI双模态探针,对合成探针的所用材料进行了综述,并在一定程度上关注了探针的靶向性、成像能力等。目前,MRI-OI双模态探针的发展的难点在于所设计的大部分探针都具有一定的局限性,难以完全满足临床要求。 |
| 英文摘要: |
| Cancer is a major cause of death, but early cancer tumors are tiny in size and difficult to detect by conventional physical examination and imaging. In recent years, the ability of probes to accurately detect cancer has received much attention. This review provides a review of the materials used to synthesize probes with some attention to the targeting and imaging capabilities of the probes with respect to the currently investigated superparamagnetic iron oxide nanoparticles, gadolinium chelates, or manganese oxide nanoparticles as MRI-OI bimodal probes in the MRI part. Currently, the difficulty in the development of MRI-OI dual-modality probes is that most of the designed probes have certain limitations to fully meet the clinical requirements. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|