| 韩雨佳,赵睿,韩莎,闫思梦,牛小慧,李红霞,李燕妮,王禄华,王坤杰.化学通报,2024,87(1):104-109. |
| 手性金属有机骨架构筑的电化学传感器对色氨酸对映体的识别 |
| RecognitionofChiralTryptophanusingElectrochemicalSensorsConstructedwithChiralMetal-OrganicFrameworks |
| 投稿时间：2023-05-16 修订日期：2023-06-10 |
| DOI： |
| 中文关键词: 金属有机骨架 手性识别 配位结合 对映体检测 电化学传感器 |
| 英文关键词:metal-Organic framework Chiral recognition Coordination Enantithesis detection Electrochemical sensor |
| 基金项目:国家自然科学基金项目(22065021,21867015)和兰州市人才创新创业项目(2022-RC-33)资助 |
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| 中文摘要: |
| 本文将金属离子(Cu(Ⅱ)), 1,10-菲啰啉(Phen)和L-谷氨酸(L-Glu)组装,使用一锅法合成了手性金属有机骨架(L-Glu-Phen-Cu(Ⅱ))。L-Glu-Phen-Cu(Ⅱ)作为一种新型的电化学传感界面,由于具有良好的对映体选择性(IL/ID=2.24),被用于对色氨酸(Trp)对映体的手性识别中。Cu(Ⅱ)和L-Glu配位实现了L-Glu-Phen-Cu(Ⅱ)立体选择性的构建,Cu(Ⅱ)和Phen配位增强了电化学信号,实现了L-Glu-Phen-Cu(Ⅱ)高对映选择性的构建。本研究不仅为高效的Trp对映体检测提供了一种易于调节、低成本的传感界面,而且将直接合成的手性MOFs用于手性识别提供了一种可行的新思路。 |
| 英文摘要: |
| The metal ions (Cu (II)), 1,10-Philoline (Phen) and L-glutamate (L-Glu) were assembled using a one-pot synthesis of the chiral metal organic skeleton (L-Glu-Phen-Cu (II)). L-Glu-Phen-Cu(Ⅱ), as a novel electrochemical sensing interface, has good enantiomeric selectivity (IL/ID=2.24) and is used for chiral recognition of tryptophan (Trp) enantiomers. The coordination of Cu (II) and L-Glu realizes the construction of L-Glu-Phen-Cu (II) stereoselectivity, and the coordination of Cu (II) and Phen enhances the electrochemical signal, realizing the construction of high enantioselectivity of L-Glu-Phen-Cu (II). This study not only provides a readily adjustable and low-cost sensing interface for efficient Trp enantiomer detection, but also provides a feasible new idea for using directly synthesized chiral MOFs for chiral identification. |
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