| 梁正会,甘春芳,刘钦洲,黄燕敏,展军颜.化学通报,2024,87(3):310-316. |
| 基于组蛋白去乙酰化酶靶点的羟肟酸类化合物及其抗肿瘤活性研究进展 |
| Research Progress in Hydroxamic Acids Based on Histone Deacetylases Targets and Their Antitumor Activities |
| 投稿时间：2023-10-06 修订日期：2023-11-01 |
| DOI： |
| 中文关键词: 组蛋白去乙酰化酶抑制剂 抗肿瘤 羟肟酸 |
| 英文关键词:HDACi Anticancer drugs Hydroxyl oxime acid |
| 基金项目:广西自然科学基金项目(2023GXNSFAA026399,2023GXNSFDA026063)、2020年广西高等学校高水平创新团队及卓越学者计划项目及第五批广西八桂学者创新团队项目资助 |
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| 中文摘要: |
| 组蛋白去乙酰化酶（histone deacetylase, HDACs）是肿瘤治疗的靶点之一，组蛋白去乙酰化酶抑制剂（histone deacetylase inhibitor, HDACi）可通过多种机制发挥抗肿瘤作用，包括抑制肿瘤细胞活力、迁移、侵袭、血管生成、增殖、DNA修复和诱导细胞凋亡。本文对近年来以HDACs为单靶点和多靶点的羟肟酸类衍生物的合成及其抗肿瘤活性进行综述，并对此方面的发展趋势、应用前景进行展望。 |
| 英文摘要: |
| Tumor therapy includes Histone Deacetylases (HDACs) as one of its targets. Through a variety of ways, histone deacetylase inhibitors (HDACi) are significant in their anti-tumor performance. It involves the stimulation of apoptosis, DNA repair, angiogenesis, invasion, migration, and viability of tumor cells. This review examined the synthesis and antitumor activity of derivatives of hydroxamic acid that had HDACs as single and multi-targets in recent years. Prospects are made regarding the trend of development and potential applications in this area. |
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