| 林嘉宇,李想,朱昱,于郁沛.化学通报,2024,87(10):1223-1228. |
| 生物样本中苯二氮卓类新精神活性物质分析方法研究进展 |
| Progress in the Biological Samples Analysis of Designer Benzodiazepines |
| 投稿时间：2024-04-05 修订日期：2024-06-06 |
| DOI： |
| 中文关键词: 苯二氮卓类新精神活性物质 生物样本 前处理 分析方法 |
| 英文关键词:designer benzodiazepines, biological samples, pretreatment, analytical methods |
| 基金项目: |
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| 中文摘要: |
| 苯二氮卓类新精神活性物质是对传统苯二氮卓类药物结构进行修饰的一类策划药物，是近几年数量增长最快的新精神活性物质之一。苯二氮卓类新精神活性物质结构多样、层出不穷、复杂多变、易滥用成瘾，而且还可被用于麻醉后实施犯罪活动，如抢劫强奸，严重危害社会安定。怎样对其进行有效的分析检验，是当前面临的问题。本文通过综述近年苯二氮卓类新精神活性物质的生物样本前处理方法、分析方法的研究进展，以期为后续分析检验工作的开展提供思路。综合来看，痕量化，高灵敏度，自动化和小型化的现场检测是未来苯二氮卓类新精神活性物质分析检验的发展方向。 |
| 英文摘要: |
| Designer benzodiazepines, a class of designer drugs that modify the structure of traditional benzodiazepines, have been among the fastest-growing new psychoactive substances in recent years. Designer benzodiazepines are structurally diverse, endless, complex, easy to abuse and addictive, and can also be used to anesthetize and then implement criminal activities, such as robbery and rape, seriously endangering social stability. And how to effectively analyze and test them is the main problem currently facing. In this paper, we review the research progress of the pre-treatment methods and analytical methods for biological samples of designer benzodiazepines in recent years, with a view to providing ideas for the subsequent development of their analytical and testing work. Overall, traceability, high sensitivity, automation and miniaturization of on-site testing are the future trends in the analysis and testing of designer benzodiazepines. |
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