| 周鑫辰,张卓,董姝含,靳茁,战星彤,沈明妹,王鹤霖,杨舒惠,刘丽梅.化学通报,2024,87(9):1098-1106. |
| G-四链体结构与DNA甲基化修饰的交互影响: 当前研究与未来展望 |
| Interaction between G-quadruplex structure and DNA methylation: current research and future perspectives |
| 投稿时间：2024-04-16 修订日期：2024-05-26 |
| DOI： |
| 中文关键词: G-四链体 DNA甲基化 CpG岛 DNA复制 染色质结构状态 |
| 英文关键词:G-quadruplexes DNA methylation CpG island DNA replication Chromatin structure state |
| 基金项目:吉林省科技发展计划项目(YDZJ2022012YTS515,YDZJ202301ZYTS168)和吉林省人社厅项目(2023RY12)资助 |
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| 中文摘要: |
| 基因表达调控是生物学中复杂而关键的过程,涉及细胞内外多因素及DNA结构。DNA双螺旋是基本形式,但非规范DNA结构如G-四链体(G4s)在基因组关键区域中广泛存在,参与调节基因表达、维持染色体稳定性和影响端粒伸长。G4s同时存在于DNA和RNA中,与基因表达调控密切相关。DNA甲基化是表观遗传标记,近年研究发现其与多种疾病疾病关联,影响细胞功能。本文综述G4与DNA甲基化的关系,特别在CpG岛区域的相互影响,为相关疾病的预防和治疗新策略。 |
| 英文摘要: |
| Gene expression regulation is a fundamental and intricate process in biology, involving various intra- and extracellular factors as well as the structural dynamics of DNA. While the double helix structure is the canonical form, non-canonical DNA structures such as G-quadruplexes (G4) are widely distributed in crucial genomic regions. These structures participate in gene expression regulation, maintain chromosome stability, and influence telomere elongation. G4 structures are found in both DNA and RNA and are closely associated with gene expression regulation.DNA methylation serves as an epigenetic marker and has been increasingly linked to various diseases, impacting cellular functions. Recent studies have illuminated the association between DNA methylation and diverse pathological conditions. This article aims to review the interplay between G4 structures and DNA methylation, particularly focusing on their mutual influence in CpG (Cytosine-phosphate-Guanine) island regions. It provides insights into novel strategies for the prevention and treatment of relevant diseases. |
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