徐新奇,张珍珍,陈小丰,陈秋水,杨黄浩.化学通报,2024,87(9):1009-1019. |
基于纳米闪烁体的X射线发光生物分子测量与疾病治疗研究进展 |
Recent Advances in Nanoscintillators-based X-ray Luminescence Biomolecule Measurement and Disease Treatment |
投稿时间:2024-04-18 修订日期:2024-05-16 |
DOI: |
中文关键词: 纳米闪烁体 X射线发光 光学探针 生物分析 |
英文关键词:Nanoscintillators, X-ray luminescence, Optical probes, Biological analysis |
基金项目:国家自然科学基金项目(22027805,22334004,22104016)和福建省自然科学杰出青年基金项目(2022J06008)资助 |
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中文摘要: |
X射线发光是指闪烁体在X射线激发下发射出低能量光子的过程,在生物传感、医学成像、光动力治疗、光遗传等领域具有应用前景。相较于传统的紫外激发光,X射线对生物组织具有高穿透性且不会触发生物体的自荧光,可实现深组织、无背景、高灵敏的生物分析。近年来,基于纳米闪烁体的X射线发光在生物光子学领域中得到广泛研究,促进了X射线发光在分析化学和生物医学中的应用。本文首先对闪烁体的X射线发光机理进行了概述,接着重点介绍了纳米闪烁体作为光学探针在生物分子测量与疾病治疗中的研究进展,包括生物传感、活体成像和光动力治疗等,最后讨论了该领域存在的一些挑战和可能的解决方案。 |
英文摘要: |
X-ray luminescence refers to the process in which scintillator emits low-energy photons under X-ray excitation. It is increasingly becoming a useful tool in biosensing, medical imaging, photodynamic therapy, optogenetics. Compared with traditional ultraviolet excitation light, X-rays have high penetration into biological tissues and do not trigger the autofluorescence of organisms, enabling deep tissue, background-free, and highly sensitive biological analysis. In recent years, X-ray luminescence based on nanoscintillators has been widely studied in biophotonics, promoting the applications in analytical chemistry and biomedicine. This review firstly provides an overview of the X-ray luminescence mechanism of scintillators, and then focuses on the research progress of nanoscintillators as optical probes in biomolecular measurement and disease treatment, including biosensing, in vivo imaging, and photodynamic therapy. Finally, some challenges and possible solutions are further discussed. |
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