| 张瑞鹤,周爱华.化学通报,2024,87(11):1319-1329. |
| 氮自由基介导的分子内δ-C(sp3)—H胺化的研究进展 |
| Research progress of nitrogen radical mediated intramolecular δ-C(sp3)—H amination |
| 投稿时间：2024-04-22 修订日期：2024-06-29 |
| DOI： |
| 中文关键词: 自由基 1,5-HAT 五元氮杂环 立体选择性 |
| 英文关键词:Free radicals, 1,5-HAT, Five-membered nitrogen heterocyclic ring, Stereoselectivit |
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| 中文摘要: |
| 氮自由基通过分子内1,5氢原子转移(1,5-HAT)可以高效地构建C—N键合成分子内五元氮杂环,并且使用特定催化剂可以较好地控制自由基的手性获得具有立体选择性的化合物,随着科学家们的深入研究,氮自由基的生成条件被不断发展,本文对通过传统化学、电化学、光化学及酶催化途径生成氮自由基,进而进行分子内δ-C—H胺化以构建五元氮杂环的相关文献进行了综述,并对部分机理进行了阐述。 |
| 英文摘要: |
| Nitrogen free radicals can efficiently construct C—N bonds to synthesize intramolecular five-membered nitrogen heterocycles through intramolecular 1,5 hydrogen atom transfer (1,5-HAT), and using specific catalysts can control the chirality of free radicals to obtain stereoselective compounds. With the in-depth research of scientists, the conditions for the formation of nitrogen free radicals have been continuously developed. In this paper, we reviewed the literature on the formation of five-membered nitrogen heterocyclic ring by intramolecular δ-C—H amination mediated by nitrogen free radicals generated through traditional chemical, electrochemical, photochemical and enzyme-catalyzed pathways, part of the mechanism is described. |
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