| 虞梦秋,舒杭琪,汪宜宇,聂作明,赵凯.化学通报,2025,88(4):392-399. |
| 酶催化交联水凝胶在组织工程的研究进展 |
| Advances in enzyme-catalyzed cross-linked hydrogels for tissue engineering |
| 投稿时间：2024-11-16 修订日期：2025-01-17 |
| DOI： |
| 中文关键词: 酶交联 水凝胶 组织工程 药物递送 |
| 英文关键词:Enzyme cross-linking,Hydrogel, Tissue engineering,Drug delivery |
| 基金项目:国家自然科学基金项目(32170844)、浙江省自然科学基金青年科学基金项目(LQN25C100008)和台州市科技计划项目(23gya01)资助 |
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| 摘要点击次数: 40 |
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| 中文摘要: |
| 通过酶催化温和交联反应制备的水凝胶具有原位形成、催化效率高、反应条件温和、细胞毒性低、生物相容性好、易降解等优点。本文阐述了酶交联水凝胶的作用机理,涵盖了转谷氨酰胺酶(TGase)、酪氨酸酶(TYR)和辣根过氧化物酶(HRP)三种酶；并综述了近年来酶交联水凝胶在组织工程的发展现状,包括皮肤组织、骨软骨组织、神经组织、细胞包封与递送和药物释放。最后对酶交联水凝胶所面临的不稳定性、机械性能有限等挑战及未来的发展趋势进行了总结和展望,为酶交联水凝胶在组织工程的研究提供了理论依据和参考价值。 |
| 英文摘要: |
| Hydrogels prepared by enzyme-catalyzed mild cross-linking reaction have the advantages of in situ formation, high catalytic efficiency, mild reaction conditions, low cytotoxicity, good biocompatibility, and easy degradation. This paper describes the mechanism of action of enzyme crosslinked hydrogels, covering three enzymes, namely transglutaminase (TGase), tyrosinase (TYR) and horseradish peroxidase (HRP); and reviews the current development of enzyme crosslinked hydrogels in recent years in the field of tissue engineering, including skin tissues, osteochondral tissues, neural tissues, cell encapsulation and delivery, and drug release. Finally, the challenges faced by enzyme crosslinked hydrogels, such as instability and limited mechanical properties, as well as the future development trends, are summarized and outlooked. It provides theoretical basis and reference value for the research of enzyme cross-linked hydrogels in tissue engineering. |
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