| 赵咪娜,唐嘉一,李连庆.化学通报,2025,88(5):544-551. |
| 噁唑化合物的合成研究进展 |
| Research progress on the synthesis of oxazoles |
| 投稿时间：2024-12-18 修订日期：2025-01-16 |
| DOI： |
| 中文关键词: 噁唑 [3+2]环加成反应 多组分串联反应 氧化环化反应 分子内环化反应 |
| 英文关键词:Oxazoles, [3+2] Cycloaddition reaction, Multi-component tandem reaction, Oxidation cyclization reaction, Intramolecular cyclization reaction |
| 基金项目:国家自然科学基金项目(22201012)、陕西省创新能力支撑计划—青年科技新星项目(2024ZC-KJXX-039)、陕西学前师范学院2024年国家级大学生创新创业训练计划项目(202414390025)和陕西学前师范学院重点(扶持)学科资助 |
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| 中文摘要: |
| 噁唑类化合物是在天然产物、药物分子中,普遍存在的一种具有重要结构骨架的物质。因其具有一系列重要的生物活性,如抗细菌、抗白血病、抗病毒和抗癌活性等,噁唑类化合物的合成一直是化学家研究的热点。本文归纳总结了近五年来国内外合成噁唑类化合物的方法并且对部分反应机理进行简述,希望为后期噁唑化合物的合成和研究提供参考及借鉴。 |
| 英文摘要: |
| Oxazoles are widely used in natural products and drug molecules, which have important structural framework. Because of their important biological activities, such as anti-bacteria, anti-leukemia, anti-virus and anti-cancer activities, the synthesis of oxazoles has been the focus of chemists. In this paper, the synthesis methods of oxazoles at home and abroad in the past five years were summarized and some reaction mechanisms were briefly introduced, hoping to provide reference for the synthesis and research of oxazoles in the later stage. |
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