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| 天然吡喃香豆素结构多样性与药理活性研究进展 |
| ?Structural Diversity and Pharmacological Activities of Natural Pyranocoumarins: A Comprehensive Review |
| 投稿时间：2025-01-25 修订日期：2025-02-25 |
| DOI： |
| 中文关键词: 天然吡喃香豆素 化学结构 抗炎 抗肿瘤 |
| 英文关键词:Natural pyranocoumarins, Chemical structure, Anti-inflammatory Antitumor |
| 基金项目:(2023GXNSFAA026476)；广西中医药大学“岐黄工程”高层次人才团队培育项目(202405)；广西中医药大学“桂派中医药传承创新团队”项目(2022B005)。 |
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| 中文摘要: |
| 吡喃香豆素是一类天然的苯并吡喃酮衍生物，在药用植物如前胡属、当归属和黄皮属等植物中广泛分布。最近的研究已经确定了五种主要的骨架类型，包括3,4-吡喃香豆素、4,5-吡喃香豆素、5,6-吡喃香豆素、6,7-吡喃香豆素和7,8-吡喃香豆素，它们的结构多样性主要来自于取代基和融合环系统位置的变化。目前，已发现239种天然吡喃香豆素类化合物，其中以6,7-吡喃香豆素和7,8-吡喃香豆素类化合物为主，分别占74个和124个。药理研究发现，天然吡喃香豆素在抗菌、抗炎、抗肿瘤以及抗HIV等方面活性显著，其中，较多6,7-吡喃香豆素类化合物被报道具有较强的抗菌及抗肿瘤活性，而7,8-吡喃香豆素类化合物更多地展现出优越的抗炎以及抗HIV活性，这可能与它们的骨架结构差异有关。综上所述，天然吡喃香豆素作为一类具有多种生物活性的天然产物，在药物研发领域具有广阔前景，后续研究应聚焦于构效关系解析与药代动力学优化，以期开发出高效低毒的新型治疗药物。 |
| 英文摘要: |
| Pyranocoumarins, a class of naturally occurring benzopyrone derivatives, are widely distributed in medicinal plants such as Peucedanum, Angelica, and Clausena species. Recent studies have identified five primary skeletal types, including 3,4-pyranocoumarins, 4,5-pyranocoumarins, 5,6-pyranocoumarins, 6,7-pyranocoumarins, and 7,8-pyranocoumarins, with significant structural diversity arising from variations in substituents and fused ring systems?12. To date, 239 natural pyranocoumarins have been isolated, among which 6,7-pyranocoumarins (74 compounds) and 7,8-pyranocoumarins (124 compounds) constitute the predominant scaffolds?. Pharmacologically, pyranocoumarins exhibit broad-spectrum bioactivities, including antimicrobial, anti-inflammatory, antitumor, and anti-HIV effects?. Notably, numerous 6,7-pyranocoumarin derivatives have been reported to demonstrate potent antibacterial and antitumor effects, while 7,8-pyranocoumarins more prominently exhibit superior anti-inflammatory and anti-HIV activities. These functional differences may be attributed to variations in their core skeleton structures. These findings underscore the potential of pyranocoumarins as multifunctional scaffolds in drug discovery. Future research should focus on elucidating structure-activity relationships (SARs) and optimizing pharmacokinetic profiles to develop novel therapeutics with enhanced efficacy and reduced toxicity?. |
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