| 白安琪,彭孔浩,孟 颖,殷 慧,宿欣瑶,罗利霞,张凌燕,李淑荣,孟佩俊.化学通报,2024,87(4):427-435. |
| 稀土掺杂上转换纳米粒子的表面功能化修饰及其生物应用 |
| Surface functionalization modification of Rare-earth-elements-doped upconversion nanoparticles and its application |
| 投稿时间：2023-10-18 修订日期：2023-11-08 |
| DOI： |
| 中文关键词: 稀土掺杂上转换纳米粒子 表面功能化修饰 应用 |
| 英文关键词:Rare-earth-elements-doped upconversion nanoparticles Surface functional modification Applications |
| 基金项目:国家自然科学基金项目(81960601,82360656)、内蒙古自治区高等学校青年科技英才支持项目(NJYT23026)、内蒙古自治区自然科学基金项目(2023MS08009,2021MS08055)、内蒙古自治区卫生健康委医疗卫生科技计划项目(202201383)、包头医学院2023年研究生科研创新项目(bycx2023006)和2023年自治区级大学生创新创业训练计划项目(S202310130001)资助 |
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| 中文摘要: |
| 稀土掺杂上转换纳米粒子(RED-UCNPs)作为一种新型高效的上转换发光纳米材料,具有反斯托克斯位移大,发射光谱窄、发光寿命长、材料毒性低等优点,已成为荧光标记、光动力学治疗、生物成像和构建生物传感器等领域的研究热点。然而,目前广泛使用的溶剂热法合成的RED-UCNPs生物相容性和亲水性差,而且不具备与生物分子之间相偶联的活性基团,因此对RED-UCNPs进行表面功能化修饰就显得格外重要。本文重点综述了RED-UCNPs的表面功能化修饰的类型及其应用现状,为RED-UCNPs的进一步研究开发和应用提供思路和参考依据。 |
| 英文摘要: |
| Rare-earth-elements-doped upconversion nanoparticles (RED-UCNPs), as a new and efficient up-conversion luminescent nanomaterials, have the advantages of large anti-Stokes shift, narrow emission spectrum, long luminescent lifetime and low material toxicity, and have become a research hotspot in the fields of fluorescence labeling, photodynamic therapy, bioimaging and biosensor construction. However, the widely used solvothermal synthesis of RED-UCNPs has poor biocompatibility and hydrophilicity, and does not have the active group coupled with biological molecules, so it is particularly important to modify the surface functionalization of RED-UCNPs. In this paper, the types of RED-UCNPssurface functionalization and its application status are reviewed, which provides ideas and references for further research, development and application of RED-UCNPs. |
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