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| 药物(S)-布洛芬合成新方法与课程思政实验设计 |
| The New Synthetic Method of Drug (S)-Ibuprofen and Ideological & Political Teaching of Experiment Design |
| 投稿时间：2024-04-01 修订日期：2024-04-14 |
| DOI： |
| 中文关键词: 不对称合成 手性辅基 课程思政 实验教学 |
| 英文关键词:Asymmetric synthesis, Chiral auxiliary, Ideology and politics course, Experimental teaching |
| 基金项目: |
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| 摘要点击次数: 15 |
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| 中文摘要: |
| 手性辅基控制的不对称合成是获取手性化合物的重要方法之一，被广泛应用于医药合成领域。基于目前手性布洛芬合成问题，研究团队发展了经Cu(OTf)2催化羰基α-位不对称芳基化反应制备手性药物(S)-布洛芬的合成新方法，并将研究成果转化为本科综合实验教学，可以帮助学生掌握多步有机合成反应操作，理解不对称合成技术对服务国家需求和维护人民生命健康的重要意义。此外，本文对实验所蕴含的思政元素进行充分挖掘，并将之与实验教学环节深入融合，最终培养学生的科学思维、创新能力、团队合作精神、专业认同感和社会责任感。 |
| 英文摘要: |
| Asymmetric synthesis using chiral auxiliary strategy is one of the important methods for the synthesis of chiral compounds, which is widely used in the field of pharmaceutical synthesis. To address the synthetic challenges posed by chiral ibuprofen, we herein reported a new synthetic method to (S)-ibuprofen via the enantioselective α-arylation of carbonyls catalyzed by Cu(OTf)2. By transforming the research achievement into the undergraduate comprehensive experiments, we hope the students could master the skill of multistep synthesis, and could understand the importance of asymmetric synthesis technology in serving national needs and maintaining human health. The ideological and political elements are fully explored, and deeply integrated with multi-link experimental teaching. The scientific consideration and innovation, as well as and the teamwork cooperation ability are to be cultivated, and also the identity of chemistry major and social responsibility will be improved for undergraduate students. |
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